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Fostering innovation and collaboration in liver research
About the Liver Center
The UCSF Liver Center is one of 17 Digestive Diseases Research Core Centers (DDRCC) in the United States, whose purpose is to enhance research productivity and collaboration among scientists with similar interests.
Research Themes of the Center
The overall focus of the Center is on integrative biology of the liver. Research in the Center is organized into 3 themes: Liver Injury, Repair & Transplantation​, Hepatic Metabolism & Metabolic Derangements, Liver Cell Biology, Plasticity & Transformation​.
Core Services of the Center
The Liver Center operates four biomedical core facilities to expedite and enhance the research performed by Center members. The Cores are designed to provide liver-specific services that are unavailable elsewhere within or outside UCSF.

​Welcome to the UCSF Liver Center

The Liver Center is a consortium of more than 60 researchers who share a common interest in liver biology and disease. The goal of the Center is to integrate bench science with clinical investigation, in support of its vision to understand and cure human liver diseases.

The physicians and scientists of the Liver Center are committed to improving understanding of liver biology and alleviating suffering from liver diseases. Read More.

Jacquelyn Maher, MD

Program Director, Liver Center


Liver Center News

Congratulations to the 2023 Pilot & Feasibility Grant Awardees!

Ana Paula Arruda, PhD

The Role of Endoplasmic Reticulum Architecture in the Development of Fatty Liver Disease

Roarke Kamber, PhD

Systematic Identification of Regulators of Kupffer-mediated Cell Clearance

Michael Li, MD, MPH

Predicting Immunotherapy Toxicity and Response in Hepatocellular Carcinoma

Carolyn Sangokoya, MD, PhD

Dynamic RNA-based Spatial Organization of Cellular Iron Regulation in Liver Development and Disease

Announcement from the Multinational Liver Societies: New “Fatty” Liver Disease Nomenclature That Is Affirmative And Non-Stigmatizing

Steatotic liver disease (SLD) is the new overarching term with metabolic dysfunction-associated steatotic liver disease (MASLD) replacing nonalcoholic fatty liver disease (NAFLD)    Read more

Featured Publications

Lu X, Deng S, Xu J, Green BL, Zhang H, Cui G, Zhou Y, Zhang Y, Xu H, Zhang F, Mao R, Zhong S, Cramer T, Evert M, Calvisi DF, He Y, Liu C, Chen X. Combination of AFP vaccine and immune checkpoint inhibitors slows hepatocellular carcinoma progression in preclinical models. J Clin Invest. 2023 Jun 1;133(11):e163291. PMID: 37040183; PMCID: PMC10231990.

Wang M, Ge J, Ha N, Shui AM, Huang CY, Cullaro G, Lai JC. Clinical Characteristics Associated With Posttransplant Survival Among Adults 70 Years Old or Older Undergoing Liver Transplantation. J Clin Gastroenterol. 2023 Jun 7. Epub ahead of print. PMID: 37279205.

Klepper A, Kung A, Vazquez SE, Mitchell A, Mann S, Zorn K, Avila-Vargas I, Kari S, Tekeste M, Castro J, Lee B, Duarte M, Khalili M, Yang M, Wolters P, Price J, Perito E, Feng S, Maher JJ, Lai J, Weiler-Normann C, Lohse AW, DeRisi J, Tana M. Novel autoantibody targets identified in patients with autoimmune hepatitis (AIH) by PhIP-Seq reveals pathogenic insights. medRxiv [Preprint].2023 Jun 27:2023.06.12.23291297. doi: 10.1101/2023.06.12.23291297. PMID: 37398174; PMCID: PMC10312872.

Groeger M, Matsuo K, Heidary Arash E, Pereira A, Le Guillou D, Pino C, Telles-Silva KA, Maher JJ, Hsiao EC, Willenbring H. Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages. Nat Commun. 2023 Jul 3;14(1):3902. doi:10.1038/s41467-023-39311-w. PMID: 37400454; PMCID: PMC10318012.

Tsusaka T, Oses-Prieto JA, Lee C, DeFelice BC, Burlingame AL, Goldberg EL. Non-specific recognition of histone modifications by H3K9bhb antibody. iScience. 2023 Jun 29;26(7):107235. doi: 10.1016/j.isci.2023.107235. PMID: 37485368; PMCID: PMC10362303.

For a complete list of liver-related member publications updated monthly, click here