Adam Gracz, PhD
Research Assistant Professor, Department of Genetics
University of North Carolina at Chapel Hill
Dissecting biliary heterogeneity with a Sox9EGFP transgene
The intrahepatic biliary epithelium plays a central role in liver function, and yet its cellular and molecular heterogeneity remains poorly understood. Our lab is utilizing a Sox9EGFP transgenic mouse model, validated in the intestinal epithelium, to define subpopulations of biliary epithelial cells. Using this approach we have been able to exploit a single biomarker to dissect cellular heterogeneity. By combining the Sox9EGFP transgene with transcriptomics, functional organoid assays, and histology, we are developing a new model for understanding cellular dynamics in the biliary epithelium.
Host: Jackie Maher, MD
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