T.S. Benedict Yen, MD, PhD
Research Interests
My research focuses on viral hepatitis, with the goals of understanding viral pathogenesis and identifying novel drug targets. Recently, we have developed a novel transgenic mouse model of hepatocarcinogenesis induced by hepatitis B virus (HBV) and are currently determining the molecular mechanisms involved. We are also characterizing a novel transcription factor that is up-regulated by the unfolded protein response and activates one of the major HBV promoters.
Selected Publications
- Huang ZM, Tan T, Yoshida H, Mori K, Ma Y, Yen TSB. Activation of Hepatitis B Virus S Promoter by a Cell-Type Restricted IRE1-Dependent Pathway Induced by Endoplasmic Reticulum Stress. Mol Cell Biol 2005;25:7522-7533.
- Zheng Y, Chen WL, Louie SG, Yen TSB, Ou JHJ. Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice. Hepatology 2007;45:16-21.
- Sir D, Chen WL, Choi J, Wakita T, Yen TSB and Ou JH. Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response. Hepatology 2008, in press.
- Professor
- Pathology
Research Theme
- Liver Injury and Repair
Contact Information
- ben.yen@
ucsf.edu - Phone: (415) 476-5334
- Fax: (415) 750-6947
- 4150 Clement St.
- Pathology 113B
- San Francisco, CA 94121
Other UCSF Affiliations
- BMS Graduate Program
- Hellen Diller Family Comprehensive Cancer Center