Melanie Ott, MD, PhD
Research Interests
My laboratory studies replication of Hepatitis C Virus (HCV) using an infectious viral clone that replicates in cell culture. We are specifically interested in viral particle assembly and the connection to lipid droplets, the endoplasmic reticulum and mitochondria. We have previously observed that a fraction of the HCV capsid protein core colocalizes with mitochondrial markers and is situated on the mitochondrial outer membrane. Our group seeks to examine whether the presence of core at the surface of mitochondria directly influences mitochondrial functions. We are specifically interested in the influence of core on molecules that regulate cellular lipid accumulation and apoptosis.
Selected Publications
- Schwer B, Ren S, Pietschmann T, Kartenbeck J, Kaehlcke K, Bartenschlager R, Yen TS, Ott M. Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol 2004;78:7958-7968.
- Nieters A, Kallinowski B, Brennan P, Ott M, MaynadiÈ M, Benavente Y, Foretova L, Cocco PL, Staines A, Vornanen M, Whitby D, Boffetta P, Becker N, de SanjosÈ S. Hepatitis C and risk of lymphoma: results of the European multi-center case-control study EPIlymph. Gastroenterology 2006;131:1879-1886.
- Hetzer C, Pedal A, Cohen MS, Bartscherer K, Kaehlcke K, Bisgrove D, Speyerer A, Taunton J, Ott M. Recruitment and Activation of RSK2 by HIV-1 Tat. PLoS One 2007;2:e151.
- Kwon H-S, Brent M, Getachew R, Jayakumar P, Chen L-F, Marmostein R, Greene WC and Ott M. Human Immunodeficiency Virus Type 1 Tat Protein Inhibits the SIRT1 Deacetylase and Induces T-Cell Hyperactivation. Cell Host Microb 2008;3:158-167.
- Associate Professor
- Medicine
- Associate Investigator, Gladstone Institute of Virology and Immunology
Research Theme
- Liver Injury and Repair
Contact Information
- mott@gladstone.ucsf.edu
- Phone: (415) 734-4807
- Fax: (415) 355-0855
- University of California, San Francisco
- 1650 Owens St.
- Box 1230
- San Francisco, CA. 94143 - 1230
Other UCSF Affiliations
- BMS graduate program