Mandana Khalili, MD, MAS
Research Interests
My research focuses on natural history of chronic viral hepatitis (hepatitis B and hepatitis C), novel treatments for viral hepatitis, and the association between hepatitis C virus (HCV) and diabetes. My group previously evaluated mechanisms of insulin resistance and secretion in a large cohort of hepatitis C patients, and is now examining how HCV affects insulin action among the high risk Latino population. We are studying insulin action over time, with and without HCV treatment, using direct measures of insulin secretion and insulin action. Through a pilot project focused on community research, we are also evaluating liver cancer screening practices in hepatitis B-infected Asians as well as patient outcomes who undergo screening for liver cancer. In addition, as one of the clinical research centers for the NIH-funded Hepatitis B Research Network, we are currently working on better understanding the natural history of chronic hepatitis B and the optimal long-term treatment for this disease.
Selected Publications
- Khalili M, Watson J, Bass N, Ascher N, Roberts J, Terrault N. New Onset Diabetes Mellitus After Liver Transplantation: The Critical Role of Hepatitis C Infection. Liver Transplantation 2004;10:349-355.
- Khalili M, Fisher E, Bernstein D, Lentz E, Barylski C, Hoffman-Terry M. Peginterferon alfa-2a With or Without Ribavirin in HCV/HIV Coinfected Patients: Partially-Blinded and Randomized Multicenter Trial. Dig Dis Sci 2005;50:1148-55.
- Khalili M, Vardanian AJ, Hamerski CM, Wang R, Bacchetti P, Roberts JP, Terrault NA. Management of hepatitis C-infected liver transplant recipients at large North-American centres: changes in recent years. Clin Transplant 2006;20:1-9.
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Kuo A, Tan V, Lan B, Khalili M, Fang S, Roberts JP, Terrault NA. Long-term histological effects of preemptive antiviral therapy in liver transplant recipients with hepatitis C virus infection. Liver Transplantation 2008 Oct;14(10):1491-7.
Associate Professor
- Medicine/Gastroenterology
Research Theme
- Hepatic Physiology and Metabolism
Contact Information
- Mandana.khalili@
ucsf.edu - Phone: (415) 206-4766
- Fax: (415) 641-0745
- San Francisco General Hospital
- 1001 Potrero Ave.
- Box 0862, NH 3D4
- San Francisco, CA. 94110
Other UCSF Affiliations
- Clinical and Translational Sciences Institute