Michael P. Busch, MD, PhD
Research Interests
My major research interests include the epidemiology, natural history, pathogenesis, and laboratory evaluation of transfusion-associated viral infections, the immunological consequences of allogeneic transfusion, and mechanisms of viral latency and reactivation following transfusion or other immunological stimuli. My laboratory is the Central Laboratory for the recently launched US and International REDS-II program, the major NIH-funded initiative supporting transfusion medicine research focused on blood safety and availability in the US and abroad. My laboratory also studies the natural history and pathogenesis of HCV infection in the blood donor and recipient settings, with the objective of defining rates and determinants of viral clearance and as well as rates and determinants for the developing liver disease.
Selected Publications
- Tseng F-C, O’Brien TR, Zhang M, Kral AH, Ortiz-Conde B.A., Lorvick J, Busch MP, Edlin BR. Seroprevalence of Hepatitis C Virus and Hepatitis B Virus among San Francisco Injection Drug Users, 1998 to 2000. Hepatology 2007;46:666-671.
- Kleinman SH, Glynn SA, Lee T-H, Tobler L, Montalvo L, Todd D, Kiss JE, Shyamala V, Busch MP. NHLBI Retrovirus Epidemiology Donor Study (REDS-II). Prevalence and Quantitation of Parvovirus B19 DNA Levels in Blood Donors Using A Sensitive PCR Screening Assay. Transfusion 2007;47:1756-1764.
- KliM.A.S.hevskaya S, Obriadina A, Ulanova T, Bochkova G, Burkov A, Araujo A, Stramer SL, Tobler LH, Busch MP, Fields HA. Distinguishing acute from chronic and resolved hepatitis C virus (HCV) infections by measurement of anti-HCV immunoglobulin G avidity index. J Clin Microbiol 2007;45:3400-3403.
- Page-Shafer K, Pappalardo BL, Tobler LH, Phelps BH, Edlin BR, Moss AR, Wright TL, Wright DJ, O’Brien TR, Caglioti S, Busch MP. Testing strategy to identify cases of acute hepatitis C virus (HCV) infection and to project HCV incidence rates. J Clin Microbiol 2008;46:499-506.
- Professor
- Laboratory Medicine
- Director, Blood Systems Research Institute
Research Theme
- Liver Injury and Repair
Contact Information
- mbusch@
bloodsystems.org - Phone: (415) 749-6615
- Fax: (415) 775-3859
- Blood Systems Research Institute
- 270 Masonic Avenue
- San Francisco, CA. 94118