Limin Liu, PhD
Research Interests
My group studies the role of S-nitroso-glutathione reductase (GSNOR) in hepatocarcinogenesis. Nitric oxide has been circumstantially implicated in tumorigenesis by means of its ability to cause DNA damage and to regulate cell growth and apoptosis; however, little is known definitively about the mechanisms through which NO regulates the behavior of pre-cancerous or cancerous cells. We previously studied mice with a targeted deletion of the GSNOR and showed that this enzyme, and thus nitrosothiol metabolism, may play a critical role in hepatocellular tumorigenesis. We are now working to elucidate the molecular mechanisms of dysregulated cell growth that result from GSNOR deficiency.
Selected Publications
- Liu L, Hausladen A, Zeng M, Loretta Que, Heitman J, Stamler JS. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Nature 2001;410:490-494.
- Matsumoto A, Comatas KE, Liu L, Stamler JS. Screening for nitric oxide-dependent protein-protein interactions. Science 2003;301:657-661.
- Liu L, Yan Y, Zeng M, Zhang J, Hanes MA, Ahearn G, McMahon TJ, Dickfeld T, Marshall HE, Que LG, Stamler JS. Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell 2004;116:617-628.
- Zaman K, Carraro S, Doherty J, Henderson EM, Lendermon E, Liu L, Verghese G, Zigler M, Ross M, Park E, Palmer LA, Doctor A, Stamler JS, Gaston B. S-nitrosylating agents: a novel class of compounds that increase cystic fibrosis transmembrane conductance regulator expression and maturation in epithelial cells. Mol Pharmacol 2006;70:1435-1442.
- Assistant Professor
- Microbiology & Immunology
Research Theme
- Progenitor Cells, Growth and Development
Contact Information
- Limin.liu@
ucsf.edu - Phone: (415) 476-1466
- Fax: (415) 476-8201
- 513 Parnassus Ave.
- Box 0414, HSE 201J
- San Francisco, CA. 94143-0414