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Laura N. Bull, PhD

Research Interests

Research in my laboratory is aimed at understanding the mechanisms underlying the development of cholestasis, through study of patients and animal models. Currently, our studies are focused on the following: (1) characterization of the differences between FIC1 disease (due to mutation in ATP8B1) and B.S.EP disease (due to mutation in ABCB11), (2) identification of genetic factors underlying intrahepatic cholestasis of pregnancy and lymphedema-cholestasis syndrome, (3) identification of factors that may influence the phenotype of patients with FIC1 disease through genetic studies to identify loci that modify phenotypes in the Fic1 mutant mouse and (4) participation in the CLiC (Cholestatic Liver Disease in Children) consortium.

Selected Publications

  • Rook M, Vargas J, Caughey A, Bacchetti P, Rosenthal P, Bull L. Fetal outcomes in pregnancies complicated by intrahepatic cholestasis of pregnancy in a Northern California cohort. PLoS One. 2012;7(3):e28343. Epub 2012 Mar 5.
  • Pawlikowska L, Strautnieks S, Jankowska I, Czubkowski P, Emerick K, Antoniou A, Wanty C, Fischler B, Jacquemin E, Wali S, Blanchard S, Nielsen IM, Bourke B, McQuaid S, Lacaille F, Byrne JA, van Eerde AM, Kolho KL, Klomp L, Houwen R, Bacchetti P, Lobritto S, Hupertz V, McClean P, Mieli-Vergani G, Shneider B, Nemeth A, Sokal E, Freimer NB, Knisely AS, Rosenthal P, Whitington PF, Pawlowska J, Thompson RJ, Bull LN. Differences in presentation and progression between severe FIC1 and BSEP deficiencies. J Hepatol. 2010 Jul;53(1):170-8.
  • Shah S, Sanford UR, Vargas JC, Xu H, Groen A, Paulusma CC, Grenert JP, Pawlikowska L, Sen S, Elferink RP, Bull LN. Strain background modifies phenotypes in the ATP8B1-deficient mouse. PLoS One. 2010 Feb 1;5(2):e8984.
  • Strautnieks SS, Byrne JA, Pawlikowska L, Cebecauerová D, Rayner A, Dutton L, Meier Y, Antoniou A, Stieger B, Arnell H, Ozçay F, Al-Hussaini HF, Bassas AF, Verkade HJ, Fischler B, Németh A, Kotalová R, Shneider BL, Cielecka-Kuszyk J, McClean P, Whitington PF, Sokal E, Jirsa M, Wali SH, Jankowska I, Pawłowska J, Mieli-Vergani G, Knisely AS, Bull LN, Thompson RJ. Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families. Gastroenterology. 2008 Apr;134(4):1203-14.
Laura Bull

Professor

  • Medicine/Gastroenterology

Research Theme

  • Hepatic Physiology and Metabolism

Contact Information

  • Rice Liver Center Laboratory
  • San Francisco General Hospital
  • 1001 Potrero Ave.
  • Bldg 40, Room 4102
  • San Francisco, CA. 94110

Other UCSF Affiliations

  • BMS graduate program
  • PSPG graduate program

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