Laura N. Bull, PhD
Research Interests
Research in my laboratory is aimed at understanding the mechanisms underlying the development of cholestasis, through study of patients and animal models. Currently, our studies are focused on the following: (1) characterization of the differences between FIC1 disease (due to mutation in ATP8B1) and B.S.EP disease (due to mutation in ABCB11), (2) identification of genetic factors underlying intrahepatic cholestasis of pregnancy and lymphedema-cholestasis syndrome, (3) identification of factors that may influence the phenotype of patients with FIC1 disease through genetic studies to identify loci that modify phenotypes in the Fic1 mutant mouse and (4) participation in the CLiC (Cholestatic Liver Disease in Children) consortium.
Selected Publications
- Knisely AS, Strautnieks SS, Meier Y, Stieger B, Byrne JA, Portmann BC, Bull LN, et al. Hepatocellular Carcinoma in ten children under five years old with bile salt export pump deficiency. Hepatology, 2006;44:478-486.
- Groen A, Kunne C, Paulusma CC, Kramer W, Agellon LB, Bull LN, Oude-Elferink RPJ. Intestinal bile salt absorption in Atp8b1 deficient mice. J Hepatol 2007;47:114-22.
- Strautnieks S, Byrne J, Pawlikowska L, Cebecauerov· D, Rayner A, Dutton L, Meier Y, et al. Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families. Gastroenterology 2008;134:1203-1214.
- Hussaini H, Bassas A, Verkade H, Groen A, Kunne C, Jongsma G, van den Oever K, Petruzelli M, Vrins C, Bull L, Paulusma C, Oude-Elferink R. Enhanced biliary cholesterol output in Atp8b1 mutant mice is Abcg5/Abcg8-independent. Gut 2008, in press.
- Associate Professor
- Medicine/Gastroenterology
Research Theme
- Hepatic Physiology and Metabolism
Contact Information
- lbull@
medsfgh.ucsf.edu - Phone: (415) 206-4807
- Fax: (415) 641-0517
- Rice Liver Center Laboratory
- San Francisco General Hospital
- 1001 Potrero Ave.
- Bldg 40, Room 4102
- San Francisco, CA. 94110
Other UCSF Affiliations
- BMS graduate program
- PSPG graduate program