Jen-Chywan Wang, PhD
The long-term goal of our research is to understand the mechanisms underlying the metabolic and anti-inflammatory effects of steroid hormones, glucocorticoids. Glucocorticoids convey their signals through glucocorticoid receptor (GR), a transcription factor, to induce specific gene expression programs in distinct cell types. This allows glucocorticoids to exert distinct metabolic functions in different tissues. Our current works are to identify GR primary target genes that mediate the metabolic actions of glucocorticoids in hepatocytes, adipocytes and myotubes, and to dissect the mechanisms governing the transcriptional regulation of these target genes. Overall, our studies apply a combinatorial approach that includes biochemistry, genetics, and physiology, to dissect the fundamental mechanisms of physiological processes and to develop novel strategies for therapeutic intervention.
- Wang JC, Shah N, Pantoja C, Meijsing SH, Ho JD, Scanlan TS, Yamamoto KR.Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity.Genes Dev. 2006 Mar 15;20(6):689-99.
- Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV Jr, Wang JC. Angiopoietin-like 4 (ANGPTL4/FIAF) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism. (2009) J Biol Chem. 284:25593-601
- Roohk DJ, Varady KA, Turner SM, Emson CE, Gelling RW, Shankaran M, Lindwall G, Shipp LE, Scanlan TS, Wang JC, Hellerstein MK. Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared to prednisolone. (2010) J Pharmacol Exp Ther. 333:281-289
- Assistant Professor
- Nutritional Science & Toxicology
Hepatic Physiology and Metabolism
- Phone: (510) 643-1039
- Fax: (510) 642-0535
- 315 Morgan Hill
- University of California, Berkeley
- Berkeley, CA 94320-3104