Daniel B. Vigneron, PhD
Research Interests
My laboratory focuses on the development the development of metabolic Magnetic Resonance Imaging (MRI) techniques for both basic research and clinical assessments of human diseases. This requires the development of new hardware/software and MR protocols to provide biochemical information in addition to the anatomic information provided by clinical MRI. The advanced MR techniques being developed by Dr. Vigneron’s group have clear value for providing improved assessment of liver metabolism. A project with Dr. Andrei Goga is focused on optimizing and applying new MR metabolic imaging techniques to characterize liver cancer models. The project aims also to assess the effects of chemotherapy agents on liver cancer models, primary hepatocytes and normal liver tissue. A second project with Dr. Aliya Qayyum is focused on applying novel MR imaging methods to provide noninvasive characterization of non-alcoholic fatty liver disease with correlations to histopathological analysis.
Selected Publications
- Cunningham CH, Chen AP, Albers MJ, Kurhanewicz J, Hurd RE, Yen Y-F, Pauly JM, Nelson SJ, Vigneron DB. Double Spin Echo Sequence For Rapid Spectroscopic Imaging of Hyperpolarized 13C. J. Magn Reson 2007;187:357-362.
- Kohler SJ, Yen Y-F, Wolber J, Chen AP, Albers MJ, Bok R, Zhang V, Tropp J, Nelson SJ, Vigneron DB, Kurhanewicz J, Hurd RE. In vivo 13Carbon Metabolic Imaging at 3T with Hyperpolarized 13C-1-Pyruvate. Magn Reson. Med 2007;58:65-69.
- Chen AP, Albers MJ, Cunnigham CH, Kohler SJ, Yen Y, Hurd RE, Tropp J, Bok R, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. High-Resolution Hyperpolarized C-13 Spectroscopic Imaging of the TRAMP mouse at 3T — Initial Experience. Magn Reson Med 2007;58:1099-1106.
- Professor
- Radiology and Biomedical Imaging
Research Theme
- Hepatic Physiology and Metabolism
Contact Information
- dan.vigneron@
radiology.ucsf.edu - Phone: (415) 476-3343
- Fax: (415) 514-4451
- Mission Bay Campus
- 1700 Fourth St.
- Box 2512, QB3 Building
- San Francisco, CA. 94143 - 2512
Other UCSF Affiliations
- QB3
- Margaret Hart Surbeck Laboratory for Advanced Imaging
- Hellen Diller Family Comprehensive Cancer Center