D. Montgomery Bissell, MD
Research Interests
My laboratory investigates tissue remodeling in liver injury. We have been focusing recently on oval cells, which are liver progenitor cells and proliferate in several forms of liver injury. Oval cells, can be isolated and, with expansion in culture, hold promise for cell-based therapy of a variety of liver diseases. We have recently defined a member of the TNF-alpha family of cytokines that appears to be a specific growth factor for a subset of oval cells. We are interested also in mechanisms of the fibrotic response to biliary injury. We have found that TGFβ and the integrin αvβ6 have key roles.
Selected Publications
- Chang ML, Chen JC, Alonso CR, Kornblihtt AR, Bissell DM. Regulation of fibronectin splicing in sinusoidal endothelial cells from normal or injured liver. Proc Natl Acad Sci USA 2004;101:18093-98.
- Kikuchi S, Griffin CT, Wang SS, Bissell DM. Role of cd44 in epithelial wound repair: migration of rat hepatic stellate cells utilizes hyaluronic acid and cd44v6. J Biol Chem 2005;280:15398-404.
- Jakubowski A, Ambrose C, Parr M, Lincecum JM, Wang MZ, Zheng TS, Browning B, Michaelson JS, Baestcher M, Wang B, Bissell DM, Burkly LC. Tweak induces liver progenitor cell proliferation. J Clin Invest 2005;115:2330-40.
- Wang B, Dolinski B, Kikuchi N, Leone DR, Peters MG, Weinreb PH, Violette SM., Bissell DM. Role of αvβ6 in acute biliary fibrosis. Hepatology 2007;46:1404-12.
- Professor
- Director Emeritus, UCSF Liver Center
- Medicine/Gastroenterology
Research Theme
- Liver Injury and Repair
Contact Information
- Montgomery.Bissell@
ucsf.edu - Phone: (415) 476-2777
- Fax: (415) 476-0659
- 513 Parnassus Avenue
- Box 0538, Room S-357
- San Francisco, California 94143-0538
Other UCSF Affiliations
- BMS Graduate Program
- Hellen Diller Family Comprehensive Cancer Center