Deanna L. Kroetz, PhD
Research Interests
My group studies the metabolism of arachidonic acid by cytochrome P450 enzymes and the regulation of this metabolism by nuclear receptors such as the peroxisome proliferator-activated receptor (PPAR). Cytochrome P450 eicosanoids are abundant in hepatic phospholipid pools and are released upon hormonal stimulation. Of particular interest are the epoxyeicosatrienoic acids (EETs), which have anti-inflammatory and metabolic effects involving disruption of NF-kB signaling and activation of PPARα. EETs are metabolized by soluble epoxide hydrolase and thus pharmacological inhibitors of this enzyme are being tested in animal models as anti-inflammatory agents. Another area of research is on the pharmacogenetics of the ABC transporters, for which a number of genetic variants have been described. A major focus of our laboratory is to characterize the functional significance of these variants including their effects on biliary secretion of drugs and other xenobiotics.
Selected Publications
- K.M. Giacomini, C.M. Brett, R.B. Altman, et al from the Pharmacogenetics Research Network. The pharmacogenetics research network: from SNP discovery to clinical drug response. Clin Pharmacol. Ther.2007; 81:328-345.
- Ng V, Falck JR, Kroetz DL. Cytochrome P450 eicosanoids are endogenous activators of peroxisome proliferator-activated receptor alpha (PPARα). Drug Metab Disp 2007;35:1126-113.
- Gow JM, Kroetz DL. The effects of ABCB1 3’-untranslated region variants on mRNA stability. Drug Metab Disp 2008;36:10-15.
- Gow JM, Hodges LM, Chinn LW, Kroetz DL. Substrate-dependent effects of ABCB1 coding region polymorphisms. J Pharmacol Exp Ther 2008;325:435-442.
- Professor
- Biopharmaceutical Sciences and Pharmaceutical Chemistry
Research Theme
- Hepatic Physiology and Metabolism
Contact Information
- Deanna.kroetz@
ucsf.edu - Phone: (415) 476-1159
- Fax: (415) 476-0688
- 1550 Fourth St.
- Box 2911, Bldg 19B 584E
- San Francisco, CA. 94143 - 2911
Other UCSF Affiliations
- PSPG graduate program