Calvin Kuo, MD, PhD
Research Interests
Research in the Kuo laboratory is focused on the biologic characterization of novel molecules regulating angiogenesis, and assessment of their use for anti-angiogenic therapy of cancer. Recent studies led to the finding that vascular endothelial growth factor (VEGF) negatively regulates erythropoietin production by hepatocytes, and that hepatocyte erythropoietin expression is under tonic regulation by paracrine VEGF from the sinusoidal endothelium. We are continuing to pursue novel means of cross-talk between hepatocytes and endothelial cells. Other interests include regulation of intestinal stem cells and functional genomics of colon cancer.
Selected Publications
- Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Niyak NR, Kuypers FA, Ma L, Sundram U, Wu G, Garcia JA, Schrier SL, Maher JJ, Johnson RS, Yancopoulos GD, Mulligan RC, Kuo CJ. VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nature Medicine 2006;12:793-800.
- Chan CKF, Chen CC, Luppen CA, Kraft DL, Kim JB, DeBoer A, Wei K, Helms JA, Kuo CJ, Weissman IL. Endochondral ossification is required for hematopoietic stem cell niche formation. Nature, (2008) Dec 10 [Epub ahead of print]
- Kuhnert F, Tam BY, Sennino B, Gray JT, Yuan J, Jocson A, Nayak NR, Mulligan RC, McDonald DM, Kuo CJ. Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesis. Proc Natl Acad Sci U S A 2008;105:10185-90.
- Harshman, LC, Kuo, CJ, Wong, BY, Vogelzang NJ and Srinivas S. Increased Hemoglobin Associated with VEGF Inhibitors in Advanced Renal Cell Carcinoma. Cancer Investigation,. (2009) Jul 13:1. [Epub ahead of print]
- Ootani A, Li X, Ueno H, Sangiorgi E, Ho QT, Toda S, Sugihara H, Fujimoto K, Weissman IL, Capecchi MR, and Kuo CJ. Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nature Medicine, Jun;15(6):701-6 (2009). Epub 27 April 2009
- Associate Professor
- Medicine/Hematology (Stanford University)
Research Theme
- Hepatic Physiology and Metabolism
Contact Information
- cjkuo@
stanford.edu - Phone: (650) 736-1428
- Stanford University
- CCSR 1155
- 269 Campus Dr.
- Stanford, CA 94305