Charles Harris, MD, PhD
Research Interests
My research focuses on mechanisms of lipid storage. In particular I am interested in the metabolic effects of glucocorticoids. Specifically, with respect to the liver I am interested in the mechanistic basis for glucocorticoid mediated hepatic insulin resistance. A second area of interest is the roles of the DGAT enzymes, which catalyze the final step in triglyceride synthesis, in health and disease. For example, in a recent collaboration with Melanie Ott’s laboratory we are studying the role of DGAT1 in hepatitis C infection.
Selected Publications
- CA Harris, K Veenstra, S Marmor, B Hubbard, B Halloran, RV Farese.Transgenic Cushingoid Mice Model the Obesogenic, Diabetogenic, and Catabolic Effects of Glucocorticoid Excess (in preparation).
- Herker E, Harris C, Farese RV Jr, Ott M. Diacylglycerol Acyltransferase 1 is a Crucial Host Factor for Hepatitis C Virus Replication. (submitted).
- Harris C, Yen CL, Stone SJ, Koliwad S, Farese RV Jr. (2008) DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res. 49(11):2283-301.
- Assistant Adjunct Professor
- Medicine/Endocrinology
Research Theme
- Hepatic Physiology and Metabolism
Contact Information
- Charles.harris@ucsf.edu
- Phone: (415) 734-2837
- Mission Bay Campus Box 1230
- 1650 Owen Street, Fourth Floor
- San Francisco, CA. 94158