Andrei Goga, MD, PhD
Tumor cells are driven to proliferate by oncogene over-expression or the loss of tumor-suppressor genes. Since tumor cells develop a deregulated cell cycle, their proliferation may be especially sensitive to cell cycle inhibitors. Cell cycle regulation has been extensively studied in simple model organisms such as yeast and in mammalian cell culture systems; however, much less is known about cell cycle regulation in the context of a whole mouse or in a developing tumor. Our group is developing mouse model systems to study basic cell cycle regulation in normal and tumor cells and to facilitate the development of cell cycle inhibitors as therapeutics. We are exploring the possibility that cyclin-dependent kinase inhibitors can induce apoptosis or senescence of tumor cells in vivo. We are also interested in identifying miRNAs that regulate oncogenes or tumor suppressor genes, and have already identified several that are differentially expressed in liver cancer.
Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA. IRE1α Cleaves Select microRNAs during ER Stress to Derepress Translation of Proapoptotic Caspase-2. Science. 2012 Oct 4.
Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12722-7.
von Morze C, Larson PE, Hu S, Yoshihara HA, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB. Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea. Magn Reson Imaging. 2012 Apr;30(3):305-11.
- Progenitor Cells, Growth and Development
- Phone: (415) 353-7070
- Fax: (415) 353-7021
- 505 Parnassus Ave.
- Box 1270, M 1283
- San Francisco, CA. 94143 - 1270
Other UCSF Affiliations
- BMS Graduate Program
- Hellen Diller Family Comprehensive Cancer Center