Andrei Goga, MD, PhD
Research Interests
Tumor cells are driven to proliferate by oncogene over-expression or the loss of tumor-suppressor genes. Since tumor cells develop a deregulated cell cycle, their proliferation may be especially sensitive to cell cycle inhibitors. Cell cycle regulation has been extensively studied in simple model organisms such as yeast and in mammalian cell culture systems; however, much less is known about cell cycle regulation in the context of a whole mouse or in a developing tumor. Our group is developing mouse model systems to study basic cell cycle regulation in normal and tumor cells and to facilitate the development of cell cycle inhibitors as therapeutics. We are exploring the possibility that cyclin-dependent kinase inhibitors can induce apoptosis or senescence of tumor cells in vivo. We are also interested in identifying miRNAs that regulate oncogenes or tumor suppressor genes, and have already identified several that are differentially expressed in liver cancer.
Selected Publications
- Yang D, Goga A, Bishop JM. RNA interference (RNAi) with RNase III-prepared siRNAs. Methods Mol Biol 2004;252:471-82.
- Scott G, Goga A, Bhaumik D, Berger C, Sullivan C, Benz C. 2007. Coordinate Suppression of ERBB2 and ERBB3 by Enforced Expression of microRNA miR-125a or miR-125b. J Biol Chem 2007;282:1479-1486.
- Goga A, Yang, D, Tward A, Morgan DO Bishop JM. 2007. Inhibition of Cdk1 as a potential therapy for tumors over-expressing MYC. Nat Med 2007;13:820-827.
- Goga A, Benz, C. 2007. Anti-oncomir suppression of tumor phenotypes. Mol Interv 2007;7:199-202.
- Assistant Professor
- Medicine/Hematology-Oncology
Research Theme
- Progenitor Cells, Growth and Development
Contact Information
- Andrei.goga@
ucsf.edu - Phone: (415) 353-7070
- Fax: (415) 353-7021
- 505 Parnassus Ave.
- Box 1270, M 1283
- San Francisco, CA. 94143 - 1270
Other UCSF Affiliations
- BMS Graduate Program
- Hellen Diller Family Comprehensive Cancer Center