September 10, 2014 | Parnassus Campus | Room S-214 | 9-10am
Steven Kliewer, PhD | University of Texas Southwestern
Professor of Molecular Biology & Pharmacology
Physiology and Pharmacology of the Metabolic Hormones FGF19 and FGF21
A focus of our laboratory is the endocrine fibroblast growth factors, FGF15/19 and FGF21. We have shown that FGF15/19 regulates bile acid homeostasis and postprandial metabolism, and that FGF21 modulates the adaptive starvation response. Recently, we demonstrated that FGF21 acts on the nervous system to regulate metabolism, physical activity and female reproduction. In ongoing studies, we seek to determine the molecular pathways whereby FGF15/19 and FGF21 mediate their pleiotropic effects.
Tom Rutkowski, PhD | University of Iowa
Associate Professor of Anatomy & Cell Biology
ER protein folding, redox, and lipid catabolism: Why they matter for fatty liver disease and liver cancer
Disruptions to homeostasis in the endoplasmic reticulum—so-called “ER stress”—lead to activation of an adaptive signaling cascade that culminates in transcriptional reprogramming. Classically, this response upregulates the expression of ER chaperones and other factors that improve ER protein folding. However, ER stress in the liver also alters the activity of lipid metabolic and inflammatory pathways. A dysregulated response to ER stress has been implicated in both fatty liver disease and liver cancer, but the mechanisms by which ER stress impinges upon metabolism and the consequences of these actions for ER homeostasis are poorly understood. In this talk I will highlight our recent work on the contribution of ER stress to hepatic steatosis and oncogenesis and the interactions between ER stress signaling, fatty acid oxidation, and the ER redox environment.
December 17, 2014 | Parnassus Campus | Room S-214 | 9-10am
Associate Professor of Pathology
Role of mesothelial cells in development, injury, and regeneration
The surface of the internal organs and body cavities is covered with a single layer of mesothelial cells. Although the major function of mesothelial cells is secretion of a lubricating fluid to facilitate movement of the internal organs, recent studies indicate that mesothelial cells act as mesenchymal progenitor cells in development, injury, and regeneration. I would like to talk about differentiation of mesothelial cells to different mesenchymal cell types in embryogenesis and organ fibrosis of the liver and body wall.
January 21, 2015 | Parnassus Campus | Room S-214 | 9-10am
Professor of Surgery
"Humanized" spheroid reservoir bioartificial liver
April 29, 2015 | Parnassus Campus | Room S-214 | 9-10am
Senior Investigator and Chief, Liver Diseases Branch
Mapping the Molecular Anatomy of HCV Infection by Functional Genomics and Chemical Biology
Dr. Liang's research focuses on the following 3 topics:
- to understand the mechanisms of action of interferon, ribavirin, and the new class of direct-acting antivirals in HCV therapy, and to explore the biological basis of treatment non-response in order to improve current treatment regimen;
- to apply molecular, biochemical, and functional genomic tools to identify and characterize structural and functional interactions between the virus, viral gene products, and the host; and
- to generate novel reagents and tools for developing and evaluating vaccines and antivirals by building and improving on currently available model systems